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        "author": "Erik Clarke",
        "author_email": "ecl@mail.med.upenn.edu",
        "bugtrack_url": null,
        "classifiers": [
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            "License :: OSI Approved :: GNU General Public License (GPL)",
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        "description": "Melt\n------------\n.. image:: https://travis-ci.org/eclarke/melt.svg?branch=master\n    :target: https://travis-ci.org/eclarke/melt\n.. image:: https://coveralls.io/repos/eclarke/melt/badge.svg?branch=master&service=github\n\t:target: https://coveralls.io/github/eclarke/melt?branch=master\n.. image:: https://badge.fury.io/py/melt.svg\n    :target: https://badge.fury.io/py/melt\n\nA nucleotide sequence melt temp calculator for Python.\n\nFeatures:\n==========\n\n- Usually within a few tenths of a degree C match to IDT's `OligoAnalyzer <https://www.idtdna.com/calc/analyzer>`_\n- Mono- and divalent cation corrections (from https://www.idtdna.com/Calc/Analyzer/Home/Definitions#MeltTemp)\n- Accurate nucleotide pair coefficents from Allawi and SantaLucia (1997)\n\nLimitations:\n============\n\n- Does not handle mismatches or dangling ends\n- Does not handle ambiguous bases\n- Does not handle RNA or DNA/RNA hybridization\n\nIf you need these features, use BioPython's `MeltingTemp <http://biopython.org/DIST/docs/api/Bio.SeqUtils.MeltingTemp-module.html>`_ module.\n \n\nInstallation\n=============\n\n.. code-block:: bash\n\n\t$ pip install melt\n\nUsage\n======\n\nFrom the command line:\n\n.. code-block:: bash\n\n\t$ Tm ATGCATGC\n\t44.4\n\t$ Tm --dna 200 --na 50 --mg 3 --dntp 0.8 ATGCATGC\n\t26.4\n\n\nAs a library:\n\n.. code-block:: Python\n\n\t>>> import melting\n\t>>> melting.temp(\"ATGCATGC\")\n\t44.387081560668946\n\t>>> melting.temp(\"ATGCATGC\", DNA_c=200, Na_c=50, Mg_c=3, dNTPs_c=0.8)\n\t26.438734864285152\n\nAcknowledgements\n================\n\nThis code is largely built on existing code from:\n\n- Sebastian Bassi (sbassi@genesdigitales.com)\n- Greg Singer (singerg@tcd.ie)\n- Nicolas Le Novere (lenov@ebi.ac.uk) \n\nSalt concentration equations adapted from IDT, with work from `Erik Clarke <https://github.com/eclarke>`_, `Sesh Sundararaman <https://github.com/sesh-sas>`_, and `Calvin Morrison <https://github.com/mutantturkey>`_.",
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